Source: http://www.thehollywoodgossip.com/2013/02/wissam-al-mana-who-is-janet-jacksons-husband/
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Thursday, February 28, 2013
This Emergency Bear Will Provide More Than Comfort in a Natural Disaster
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Wednesday, February 27, 2013
Arkansas lawmakers override governor's abortion bill veto
LITTLE ROCK, Ark. (AP) ? The Arkansas House voted 53-28 Wednesday to override Gov. Mike Beebe's veto of a bill that would outlaw most abortions starting in the 20th week of pregnancy, hours after a state Senate committee approved a package of even tighter abortion restrictions.
The Republican-controlled state Senate, which overwhelmingly backed the 20-week near-ban on abortions before Beebe, a Democrat, vetoed it, was expected to discuss whether to vote to override the veto Thursday. Like the GOP-led House, only a simple majority in the Senate is needed to override a veto.
The House-sponsored measure is based on the disputed argument that a fetus can feel pain by the 20th week of pregnancy, and thus deserves protection from abortion. Beebe vetoed the bill Tuesday, saying it contradicts the U.S. Supreme Court's 1976 Roe v. Wade decision, which legalized abortion until a fetus can viably survive outside of the womb, which is typically at 22 to 24 weeks.
"This is not just any regular bill. It's one that has an eternal impact on each of us and to those children," Republican Rep. Andy Mayberry told House members as he urged them to override.
Two of the House's 48 Democrats joined with all 51 GOP members to support overriding Beebe's veto. Eighteen Democrats and the chamber's only Green Party member did not vote on the override, which has the same effect as voting against it. Republicans hold 21 of the 35 seats in the Senate, which approved the bill on a 25-7 vote last week.
Before the House vote, the Senate Public Health, Welfare and Labor Committee voted 5-2 to advance a bill that would ban most abortions starting in the 12th week of pregnancy, sending it to the full Senate. The Senate passed an earlier version of the bill that would have outlawed abortions as early as six weeks into a pregnancy, but amended it to push back the restriction and to add more exemptions.
Beebe declined to say Wednesday whether he also would veto the Senate's proposed 12-week ban, but he said he thinks it's on even shakier legal ground than the House's 20-week version.
"I'm pretty sure I know what I'm going to do on a bill that's even more problematic than the one I already vetoed, but I won't tell you officially until that time," Beebe said Tuesday.
Seven states have enacted similar 20-week restrictions based on the fetal pain argument, according to the Guttmacher Institute, which tracks laws affecting women's health. A similar law in Arizona has been blocked while a federal appeals court reviews a lawsuit challenging it.
The Arkansas bill is based on research Mayberry and other abortion opponents cite that fetuses can feel pain at 20 weeks. The American College of Obstetricians and Gynecologists, however, says it knows of no legitimate scientific information supporting the idea that a fetus experiences pain.
John DiPippa, dean emeritus of the University of Arkansas at Little Rock's law school, said he agrees with Beebe that the ban is unconstitutional and likely will be decided by the courts. He said he thinks the fetal pain argument will lose in the lower courts but that it's unclear how it might fare if it were to reach the U.S. Supreme Court.
"The core holding of Roe is that a state cannot place an obstacle in the way of a woman who wants to abort before viability," DiPippa said. "If you apply that standard, then these bills that draw the line at 20 weeks ? which by all medical estimates is prior to viability ? would clearly set up a substantial obstacle to a woman's ability to before that age."
GOP Sen. Jason Rapert said he hopes Beebe lets it stand but said he was confident the 12-week ban would have enough support to override a veto.
"The governor has his own conscience," Rapert, R-Conway, told reporters. "I think probably the best route would be that he just simply not sign the bill and let it become law, if that's what he decides to do. If he doesn't, then we'll override the veto and it'll become law in the state of Arkansas."
___
Associated Press writer Michael Stratford contributed to this report.
___
Andrew DeMillo can be reached at www.twitter.com/ademillo
Source: http://news.yahoo.com/ark-house-overrides-veto-abortion-restrictions-214013377--politics.html
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Super Sync Sports makes Chrome sync between devices fun!
The latest Chrome Experiment out of Google shows off the power of sync between devices with a fun little game called "Super Sync Sports". Head to google.com/supersyncsports on your computer and g.co/super on your phone or tablet (Android 4.0 and above), enter the code to get them synced up and you're off to the races. Literally. You use your phone or tablet as a controller, with the computer display as just a portal to view the game. Select a character, and you can run, swim or bike against the computer or friends that you invite.
It's a fun game to play, especially with more than one device, but it what it really shows off is the power of Chrome to provide real-time syncing between devices using just a browser. When on Wifi, there isn't any perceptible lag between actions on the phone and the response on the screen, which is quite impressive considering that you're just using an HTML5 game in two browsers.
Google loves to do fun little experiments like this, and when they show it off to the public it's even better. Hopefully this means that it is planning to leverage these technologies in user-facing Chrome products in the future. Head to the source links to learn a bit more about how it works and to play the game for yourself.
Source: Google; More: Play Super Sync Sports
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Source: http://feedproxy.google.com/~r/androidcentral/~3/AhT-3CpErKc/story01.htm
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MWC: OpenSignal wins and Investment award for ... - What Mobile
OpenSignal, the network mapping tool, has won the Smart UK Project award for the UK?s most innovative mobile company at Mobile World Congress.
A collaborative project between UK Trade & Investment and its media partner for Mobile World Congress (MWC) XL Communications, Smart UK Project aimed to celebrate UK innovation and showcase the best examples of mobile UK mobile innovation.
All finalists won a ticket to Mobile World Congress, where OpenSignal was announced as the winner.
What does it do, now?
What Mobile had a run down of the start ups who made it through to the finals here. ?OpenSignal?s Android app has been around for a while ? the Apple version is imminent, the company said. ?In short, OpenSignal maps cellphone and WiFi coverage across ?networks. ?Using signal strength readings from your and other phones, the app produces a coverage map, which can be set to 2G, 3G and 4G, as well as WiFi hotspots and given networks.
UK Minister for Culture, Communications and Creative Industries Ed Vaizey presented the award to OpenSignal chief executive Brendan Gill, who said the company was delighted to win.
?The UK is such a hotbed of innovation and the quality of the finalists was so high.?
The judging panel included Telefonica Europe vice president Mike Short, Mobile ?Industry Review?s Ewan MacLeod and TheAlloy director Geoff McCormick, who said the quality of the finalists, including Paddle and RealVNC, was impressive.
?The judges? decision was strongly influenced by the value that OpenSignal brings to mobile users by providing them with the best signal for their phone.?
The competition began in November with 70 entries, looking for smaller companies with ideas that had the potential to disrupt the mobile industry globally.
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Twitter announces support for Firefox OS, app to be in Firefox Marketplace when devices ship
Twitter has announced that they will be among the first marquee applications to support Firefox OS. Mozilla announced yesterday that Firefox has committed mobile operators in 18 markets, and that Alcatel, ZTE, and Huawei are partnered to build devices for the new OS.
The interface they are showing looks very much like the Android app, and Twitter says the application offers a rich experience, and is easy to use. In addition to the standard functions, Twitter plans to take advantage of Firefox OS' unique Web Activity feature, and users will be able to tweet out from any app that supports them.
For more information about Firefox OS, visit Mozilla's blog, and for information about Twitter for Firefox visit the source link.
Source: Twitter
| |
Source: http://feedproxy.google.com/~r/androidcentral/~3/OxVY2N802V4/story01.htm
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Saturday, February 23, 2013
New flu drug stops virus in its tracks
Friday, February 22, 2013
A new class of influenza drug has been shown effective against drug-resistant strains of the flu virus, according to a study led by University of British Columbia researchers.
Published online today in the journal Science Express, the study details the development of a new drug candidate that prevents the flu virus from spreading from one cell to the next. The drug is shown to successfully treat mice with lethal strains of the flu virus.
In order to spread in the body, the flu virus first uses a protein, called hemagglutinin, to bind to the healthy cell's receptors. Once it has inserted its RNA and replicated, the virus uses an enzyme, called neuraminidase, to sever the connection and move on to the next healthy cell.
"Our drug agent uses the same approach as current flu treatments ? by preventing neuraminidase from cutting its ties with the infected cell," says UBC Chemistry Prof. Steve Withers, the study's senior author. "But our agent latches onto this enzyme like a broken key, stuck in a lock, rendering it useless."
The World Health Organization estimates that influenza affects three to five million people globally each year, causing 250,000 to 500,000 deaths. In some pandemic years, the figure rose to millions.
"One of the major challenges of the current flu treatments is that new strains of the flu virus are becoming resistant, leaving us vulnerable to the next pandemic," says Withers, whose team includes researchers from Canada, the UK, and Australia.
"By taking advantage of the virus's own 'molecular machinery' to attach itself," Withers adds. "The new drug could remain effective longer, since resistant virus strains cannot arise without destroying their own mechanism for infection."
###
University of British Columbia: http://www.ubc.ca
Thanks to University of British Columbia for this article.
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Source: http://www.labspaces.net/126979/New_flu_drug_stops_virus_in_its_tracks
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Underlying mechanisms behind chronic inflammation-associated diseases revealed
Feb. 22, 2013 ? Inflammatory response plays a major role in both health protection and disease generation. While the symptoms of disease-related inflammatory response have been know, scientists have not understood the mechanisms that underlie it.
In a paper published Feb. 21 in Cell Reports, a team lead by Xian Chen, associate professor of biochemistry and biophysics and member of the UNC Lineberger Comprehensive Cancer Center, mapped the complex interactions of proteins that control inflammation at the molecular level.
The inflammatory response acts as a first line of defense for the immune system. Cytokines are generated to contain infection, preventing the occurrence or spread of diseases, including cancerous tumors. An overproduction or underproduction of these cytokines during disease-related inflammatory responses can lead to a variety of disease such as arthritis, asthma and some kinds of cancer.
The team found that chronic inflammatory response is mediated by the interaction of the protein phosphatase PP2Ac and an adaptor protein of Toll-like receptors (TLRs) MyD88 in a type of the immune cells (macrophages) showing tolerance to persistent stimulation of endotoxin (LPS).
Within endotoxin-tolerized macrophages, "PP2Ac is constitutively activated and operates on a switch that exists to convert pro-inflammatory MyD88 to immunosuppressant MyD88," said Chen.
Studying interactions of the protein network that underlies inflammation, the research team found that PP2Ac disrupts the pro-inflammatory signaling pathway mediated by the complex of MyD88 and TLR4. As a result of this disruption, both constitutively active PP2Ac and MyD88 move within the cellular nucleus, where they bound with the epigenetic machinery and alter the chromatin structure of a class of pro-inflammatory genes that leads to the silencing of this class of the genes.
"In the nucleus, in a MyD88-dependent way constitutively active PP2Ac reprograms the epigenetic machinery," said Chen.
With the discovery of PP2Ac behavior, Chen's research establishes a previously unknown link between cellular signaling and epigenetic regulation, which affects the genetic blueprint of inflammation. By mapping out the signaling pathway, as well the epigenetic machinery targeted by abnormally activated PP2Ac within the cells under chronic inflammation, the research identifies potential targets of immunomodulation for future therapies for inflammation-related disorders and cancers.
"Not only did we identify individual targets, but we also identified those interconnected targets in networks of dynamic protein interactions. That will set up the base for future network medicine, as targets on single genes and targets can have off-target side effects. To increase the precision of the drug targets, we reveal individual proteins but also their interactions as targets," said Chen.
This work is supported by NIH grants to Dr. Chen(NIH R01AI064806 and NIH 1U24CA160035).
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The above story is reprinted from materials provided by University of North Carolina School of Medicine.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Ling Xie, Cui Liu, Li Wang, Harsha?P. Gunawardena, Yanbao Yu, Ruyun Du, Debra?J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen?P. Holly, Leslie?V. Parise, Yisong Y. Wan, Jenny?P. Ting, Xian Chen. Protein Phosphatase 2A Catalytic Subunit ? Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.01.029
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/fuRr8-XpXzU/130222143135.htm
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Feds join civil lawsuit against Lance Armstrong
WASHINGTON (Reuters) - Disgraced cyclist Lance Armstrong has failed to talk the U.S. government out of suing him to recover sponsorship money that the U.S. Postal Service paid his teams to compete in international events, Armstrong's lawyer said on Friday.
Lawyer Robert Luskin said: "Lance and his representatives worked constructively over these last weeks with federal lawyers to resolve this case fairly, but those talks failed because we disagree about whether the Postal Service was damaged."
"The Postal Service's own studies show that the service benefited tremendously from its sponsorship - benefits totaling more than $100 million," the lawyer said in a statement.
A U.S. Justice Department spokeswoman had no immediate comment.
Former Armstrong teammate Floyd Landis was believed to have filed a sealed whistleblower suit against Armstrong in 2010. A decision by the government to join the suit would trigger its unsealing.
Public court records did not indicate that a lawsuit had been filed as of mid-day on Friday.
(Reporting by David Ingram; Editing by Howard Goller and Vicki Allen)
Source: http://news.yahoo.com/lance-armstrong-lawyer-says-settlement-talks-fail-fraud-172909195--spt.html
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Friday, February 22, 2013
Facebook?s Data Breach ? A Dangerous Possibility?
Facebook?s data centers are a goldmine for hackers. It?s not a question of ?if?, but ?when? will these hackers try to take control of the servers. With increasing number of threats on the internet, Facebook cannot remain insulated forever. And when it does come under attack, a huge cache of personal data will be at stake. It could result in cutting short e-commerce?s lifetime.
However, the good news is that the top talent at Facebook is now a part of their security team. Facebook is spending huge amounts to ensure there is no loss of privacy. Many white hats are being paid cash to identify holes or bugs.
Recently, Facebook was under a ?sophisticated? malware attack. Many of the Facebook engineers came under attack when they visited particular websites. But the authorities soon came to know of it and took the necessary actions. The police was called in and investigations have already begun. It seems the hackers were after the company?s trade secrets but did not manage to get anything. Anyhow, it is just a preview of what may happen in the future.
The Facebook database is considered to be one of the biggest on the planet. And till now, it has been able to keep the information secure. Others, though, have not been so lucky. Recently, 250,000 accounts from Twitter were accessed by hackers. Apart from this, passwords of 6.5 million accounts on LinkedIn were leaked onto the internet.
Facebook is different. Most of the data on LinkedIn and Twitter is already public whereas Facebook has strict privacy settings. Most of its data is hidden by default. This also means that there is a lot to lose for Facebook in case it gets hacked. In such a case, a few of users? pictures and messages may be stolen. Or some credit card particulars might get into the public. But Facebook is ready for such a situation and will immediately quarantine the affected accounts. This is till the users log in and change their passwords.
All this may not affect the users much but the trust will surely be broken. News agencies are always on the lookout for some big story. Such a story will certainly be inflated and told across all regions. And that is when the panic could start. It probably would be a comical situation too. This is because most of the people would be sharing such stories on their Facebook accounts. So Facebook, itself, would be propagating propaganda against it. Most people might not log off from Facebook permanently, but doubts will start cropping up in their minds. The already bad hit stock price would probably fall further.
Mark Zuckerberg?s law of content sharing increases the fears too. The law says that amount of shared content is doubled each year. This means that hackers can access more and more secret information. This combined with the fact that there is already a perception about Facebook?s privacy settings being deliberately confusing, could compound the fears.
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Source: http://www.thetechlabs.com/tech-news/facebooks-data-breach-a-dangerous-possibility/
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AP Source: 3 former Miami coaches want case tossed
CORAL GABLES, Fla. (AP) ? Three former Miami assistant coaches filed a motion on Thursday with the NCAA asking that their infractions cases be dismissed because of the mistakes that governing body for college athletics made in their long investigation of the Hurricanes.
Former football assistant Aubrey Hill and former basketball assistants Jake Morton and Jorge Fernandez had their motion delivered to the NCAA's Committee on Infractions, according to a person who spoke to The Associated Press on condition of anonymity because neither side authorized the release of any information.
The motion, according to the person, says the three coaches believe the NCAA's alliance with the attorney for the former booster at the center of the Miami scandal has created a scenario where they cannot "get a fair and reasonable proceeding."
A conference call on the matter is scheduled for Friday with the NCAA.
"It's unprecedented that all this is happening, and happening this way," the person said.
The NCAA believes Hill and Fernandez provided them with misleading information during the probe into Miami athletics, and cited them as believed to be in violation with what's known as Rule 10.1 ? the broad one governing ethical conduct. Morton was also cited in the case against the Hurricanes, after the NCAA said he, among other things, accepted "supplemental income" of at least $6,000 from the former booster, Nevin Shapiro.
Miami received its notice of allegations from the NCAA on Tuesday. In that letter, the NCAA said the Hurricanes had a "lack of institutional control" for the way they failed to monitor Shapiro, a convicted felon who provided cash, gifts and other items to players on the football and men's basketball teams over a span of about eight years.
Shapiro is currently serving a 20-year prison term for masterminding a $930 million Ponzi scheme.
It's unknown when the committee will decide anything related to the motion. The NCAA has told other coaches named in the notice of allegations, including Missouri basketball coach Frank Haith, that responses to the letter are due by May 20 ? and that the case may not be heard by the infractions committee until July unless all parties involve agree to an expedited schedule.
The case that will be presented on behalf of Hill, Morton and Fernandez is also expected to include the assertion that since the NCAA cooperated with Shapiro attorney Maria Elena Perez ? who deposed two witnesses that the NCAA wanted to hear from as part of her client's bankruptcy case and used subpoena power to do so, a tool the association does not have in its arsenal ? that fraud was also perpetrated on the bankruptcy court.
The news of the motion was just one part of yet another busy day as it relates to the Miami-NCAA saga, which almost seemed to be dragging along for the better part of two years before this wild week filled with acknowledgements of wrongdoing by investigators, the delivery of the actual charges, two extremely sharp-tongued statements issued by University President Donna Shalala about the process and now what essentially amounts to legal wrangling.
And one Florida state lawmaker has now called the NCAA's probe of the Hurricanes "a witch hunt."
At Louisville, the Cardinals have made the decision to keep assistant coach Clint Hurtt on staff while he answers NCAA allegations of ethical misconduct while he was an assistant with the Hurricanes. Louisville athletic director Tom Jurich said he doesn't see a need to change Hurtt's role or status with the program right now, but that he couldn't say whether Hurtt will be with Louisville next season.
"Clint is due his due process," Jurich said. "I think that's the only fair thing that we can do as a university. Clint's side of the story is much different than the allegations are so I think we wait the 90 days and see how it unfolds then."
Like Hill and Fernandez, Hurtt faces a charge that he breached the ethical-conduct provision from the NCAA.
A person familiar with the matter told The AP that the Rule 10.1 charge against Hurtt largely stems from the NCAA's belief that he was not truthful in a November 2011 interview with investigators, one that included questions about whether he provided improper meals, transportation and some lodging for a small number of recruits and players.
Also Thursday, a member of the Florida Senate wrote the state's Attorney General, asking that the NCAA be investigated for what he called "lack of institutional control" on the association's part.
Sen. Joseph Abruzzo wrote Attorney General Pam Bondi, saying that NCAA investigators "engaged in corrupt behavior in an attempt to manufacture misdeeds against the University of Miami" and in doing so, may have actually violated Florida law.
"I am requesting that the NCAA's admitted wrongdoing be investigated immediately before the NCAA's witch hunt against the University of Miami causes further damage," Abruzzo wrote.
Source: http://news.yahoo.com/ap-source-3-former-miami-coaches-want-case-015051829--spt.html
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Stem cell 'homing' signal may help treat heart failure patients
Feb. 21, 2013 ? In the first human study of its kind, researchers activated heart failure patients' stem cells with gene therapy to improve their symptoms, heart function and quality of life, according to a study in the American Heart Association journal Circulation Research.
Researchers delivered a gene that encodes a factor called SDF-1 to activate stem cells like a "homing" signal.
The study is unique because researchers introduced the "homing" factor to draw stem cells to the site of injury and enhance the body's stem cell-based repair process. Generally, researchers extract and expand the number of cells, then deliver them back to the subject.
"We believe stem cells are always trying to repair tissue, but they don't do it well -- not because we lack stem cells but, rather, the signals that regulate our stem cells are impaired," said Marc S. Penn, M.D., Ph.D., Director of Research at Summa Cardiovascular Institute in Akron, Ohio, and lead author and professor of medicine at Northeast Ohio Medical University in Rootstown, Ohio.
SDF-1 is a naturally occurring protein, secreted by cells, that guides the movement of other cells. Previous research by Penn and colleagues has shown SDF-1 activates and recruits the body's stem cells, allowing them to heal damaged tissue. However, the effect may be short-lived. For example, SDF-1 that's naturally expressed after a heart attack lasts only a week.
In the study, researchers attempted to re-establish and extend the time that SDF-1 could stimulate patients' stem cells. Study participants' average age was 66 years.
Researchers injected one of three doses of the SDF-1 gene (5mg, 15mg or 30mg) into the hearts of 17 patients with symptomatic heart failure and monitored them for up to a year. Four months after treatment, they found:
- Patients improved their average distance by 40 meters during a six-minute walking test.
- Patients reported improved quality of life.
- The heart's pumping ability improved, particularly for those receiving the two highest doses of SDF-1 compared to the lowest dose.
- No apparent side effects occurred with treatment.
"We found 50 percent of patients receiving the two highest doses still had positive effects one year after treatment with their heart failure classification improving by at least one level," Penn said. "They still had evidence of damage, but they functioned better and were feeling better."
The findings indicate people's stem cells have the potential to induce healing without having to be taken out of the body, Penn said.
"Our study also shows gene therapy has the potential to help people heal their own hearts."
At the start of the study, participants didn't have significant reversible heart damage, but lacked blood flow in the areas bordering their damaged heart tissue.
The study's results -- consistent with other animal and laboratory studies of SDF-1 -- suggest that SDF-1 gene injections can increase blood flow around an area of damaged tissue, which has been deemed irreversible by other testing.
Researchers are now comparing results from heart failure patients receiving SDF-1 with patients who aren't. If the trial goes well, the therapy could be widely available to heart failure patients within four to five years, Penn said.
Co-authors are Farrell O.Mendelsohn, M.D.; Gary L. Schaer, M.D.; Warren Sherman, M.D.; MaryJane Farr, M.D.; Joseph Pastore, Ph.D.; Didier Rouy, M.D., Ph.D.; Ruth Clemens, M.P.H.; Rahul Aras, Ph.D., and Douglas W. Losordo, M.D.
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/yX7noIwbMMI/130221194233.htm
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Good Reads: A family in isolation, Pakistan's difficult present, Africa's biggest game
This week's good reads includes a profile of a Russian family that lived in isolation for 40 years, a young professor's return to Pakistan from the United States after 13 years, and efforts to end big game hunting in Africa.
A lion rests in the grass plains of the Maasai Mara game reserve in Kenya.
Melanie Stetson Freeman/Staff/File
EnlargeIn 1978, a group of Soviet geologists trying to land their helicopter in the taiga (thick wilderness) of remote Siberia saw startling evidence of human life. Soon they found the Lykov family ? who had been living in an encampment for more than 40 years with no contact with the outside world.
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Mike Dash, writing for Smithsonian.com, recounts their incredible story and the chance meeting that brought it to light. The Lykovs were Old Believers, a fundamentalist Russian Orthodox sect that had been persecuted since the days of Peter the Great. In 1936, after his brother was shot and killed by a Communist patrol, Karp Lykov took his wife, Akulina, and two young children and fled into the forest.
For 40 years the family eked out a living in the unforgiving Siberian wilderness, ?permanently on the edge of famine.? Two more children were born. Akulina died of starvation in 1961 when a June snow destroyed the family?s small crop. The Soviet scientists were astounded to learn that the family had no knowledge of World War II, the moon landing, or any other major development of modern society of the past half century. The two youngest children had never seen a person outside their own family.
But over the next few years, says Mr. Dash, as ?the Soviet geologists got to know the Lykov family, they realized that they had underestimated their abilities and intelligence.?
The family at first spurned, then gradually accepted most of the modern technology they saw at the scientists? research camp nearby. When, during this period, three of the Lykovs died, scientists tried to convince Karp and his daughter Agafia to leave the wilderness, but they chose to rebuild their small cabin and stay on.
After Karp died in 1988, Agafia, the youngest child, again refused to leave the life her family had forged ? and the only one she has ever known. ?A quarter of a century later, now in her seventies herself, this child of the taiga lives on alone, high above the Abakan.?
Pakistan, a forbidden love
For Taymiya Zaman, Pakistan is not Osama bin Laden or blasphemy laws or drone attacks. It is her homeland, a place of rich culture and history, struggling under the weight of change and competing stereotypes. But for many people in the United States, where she is a history professor, Pakistan is a harbor for terrorists or the scene of poor brown children waiting for Western benevolence.
Ms. Zaman?s rich personal essay appears in Tanqeed, an online magazine of politics and culture that focuses on Pakistan. Her essay first ran in the quarterly magazine Critical Muslim.
Tired of the questions and accusations surrounding her nationality, Zaman ?builds a wall? around Pakistan. Finally, weary of the disconnect, and against the advice of her colleagues, she returns to Lahore for a sabbatical year. It will be the longest she?s been home since leaving for college 13 years earlier.
She describes the homecoming: ?Landing in Karachi is like running into the arms of a lover you?ve been forbidden to see for years.? Once there, however, she gains ?the realization that I can?t hide from the things about being here that leave me troubled and edgy.? She is heckled by a bearded student who accuses her of disrespecting Islam. The traffic congestion is overwhelming.
Zaman returns to her teaching position in San Francisco with newfound appreciation for the US and enduring love for her Pakistan. ?I know the newspaper images that fuel Pakistan-bashing. I know the minefields of personal sorrow and betrayal that don?t make it to newspapers. I also know a Pakistan beneath these images that is rich with extraordinary possibilities....?
Take photos, not big game, on safari
On Foreign Policy Blogs, Daniel Donovan writes of Botswana?s recent decision to ban big-game trophy hunting by 2014. Zambia followed suit soon after by banning hunting of lions and leopards.
Botswana?s move has inspired both praise and criticism. In spite of short-term setbacks to the hunting industry, Mr. Donovan points to Kenya?s thriving nonhunting safari business as a sign of greater long-term economic gains in banning trophy hunting.
?While hunters and hunting advocates point to large profits being made in hunting of animals in Africa ... the reality is that photographic tourism far outdistances any money made in hunting safaris,? he writes. Big-game hunting in Africa has always held an allure for the rich and famous, but one study in Botswana showed that trophy hunting only represented approximately 0.1 percent of gross domestic product, as opposed to phototourism, which yields 11 percent. And as Zambia?s tourism minister, Sylvia Masebo, put it: ?Tourists come to Zambia to see the lion and if we lose the lion we will be killing our tourism industry.?
Donovan concedes that ?[c]ritics of the decision argue that it will encourage poaching over the long-term,? which has reached alarming levels in Kenya. But ?even countries that encourage trophy hunting are not immune from illegal hunting,? as revelations of poaching violations in South Africa and Tanzania show.
?Ultimately, each country must decide which direction will benefit them both ecologically and economically.?
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Starwood to open new Westin-branded property in California
Formerly known as Le Rivage Hotel, the 100-room property will undergo a $3.2 million renovation prior to re-opening under the Westin flag.
Upon completion the renovated Westin Sacramento will feature 100 guestrooms and suites, many with balconies overlooking the river, which will provide a scenic view to the guests.
Apart from the upgraded upscale guestrooms, the hotel will also provide an array of amenities like 7,000 square feet of meeting and function space, a full-service restaurant, outdoor pool, spa, and fully renovated fitness studio, where guests will have plenty of choices for cardio, strength and stretching.
Located at 4350 Riverside Boulevard, the Westin Sacramento enjoys proximity to several local attractions. The Westin Sacramento is scheduled to open in April 2013 alongside the Sacramento River.
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Theater Review: ?Isaac?s Eye? at Ensemble Studio Theater
[unable to retrieve full-text content]?Isaac?s Eye,? by Lucas Hnath, imagines Isaac Newton as an ambitious young man hoping to win admission to the Royal Society.
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Thursday, February 14, 2013
Study finds clues to why most babies in China survived melamine-tainted milk in 2008 scandal
WASHINGTON - Scientists wondering why some children and not others survived one of China's worst food safety scandals have uncovered a suspect: germs that live in the gut.
In 2008, at least six babies died and 300,000 became sick after being fed infant formula that had been deliberately and illegally tainted with the industrial chemical melamine. There were some lingering puzzles: How did it cause kidney failure, and why wasn't everyone equally at risk?
A team of researchers from the U.S. and China re-examined those questions in a series of studies in rats. In findings released Wednesday, they reported that certain intestinal bacteria play a crucial role in how the body handles melamine.
The intestines of all mammals teem with different species of bacteria that perform different jobs. To see if one of those activities involves processing melamine, researchers from the University of North Carolina at Greensboro and Shanghai Jiao Tong University gave lab rats antibiotics to kill off some of the germs ? and then fed them melamine.
The antibiotic-treated rats excreted twice as much of the melamine as rats that didn't get antibiotics, and they experienced fewer kidney stones and other damage.
A closer look identified why: A particular intestinal germ ? named Klebsiella terrigena ? was metabolizing melamine to create a more toxic byproduct, the team reported in the journal Science Translational Medicine.
Previous studies have estimated that fewer than 1 per cent of healthy people harbour that bacteria species. A similar fraction of melamine-exposed children in China got sick, the researchers wrote. But proving that link would require studying stool samples preserved from affected children, they cautioned.
Still, the research is pretty strong, said microbiologist Jack Gilbert of the University of Chicago and Argonne National Laboratory, who wasn't involved in the new study.
More importantly, "this paper adds to a growing body of evidence which suggests that microbes in the body play a significant role in our response to toxicity and in our health in general," Gilbert said.
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Source: http://www.huffingtonpost.ca/2013/02/13/study-finds-clues-to-why-_n_2680134.html
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The more things change, the more they stay the same. Will the Catholic church ch...
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Source: http://www.facebook.com/BilericoProject/posts/431606456909928
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Thursday, February 7, 2013
Scientists discover how chromosomes keep their loose ends loose
Feb. 5, 2013 ? We take it for granted that our chromosomes won't stick together, yet this kind of cellular disaster would happen constantly were it not for a protein called TRF2. Now, scientists at The Scripps Research Institute (TSRI) have discovered key details of how TRF2 performs this crucial chromosome-protecting function. The finding represents a significant advance in cell biology and also has implications for our understanding of cancer and the aging process.
"Cells tend to interpret their chromosome ends as sites of DNA damage, and without TRF2, they would attempt to 'repair' these sites by fusing different chromosomes together," said TSRI Assistant Professor Eros Lazzerini Denchi. "The prevailing view has been that TRF2 has a passive role in hiding chromosome ends from the DNA repair machinery, but we found that it also actively suppresses the repair response."
Lazzerini Denchi is the corresponding author of the new study, which is reported in an Advance Online Publication of the journal Nature on February 6, 2013.
A Protective Cap
TRF2 is part of a protective protein cap localized at the ends of chromosomes, the telomeres. Telomeres shorten with every cellular division, and when they become too short -- in aged organisms, for example -- TRF2 is no longer able to localize at chromosome ends. In such cases, chromosome ends become exposed and the DNA repair response is liable to knit uncapped chromosomes to each other. This action results in strings of chromosomes fused together that are unstable and can lead to cell death or, in some cases, to uncontrolled growth leading to cancer.
In 2007, as a postdoctoral researcher at The Rockefeller University, Lazzerini Denchi found that TRF2 works in part by blocking a particular signaling pathway in the DNA damage response. In the new study, he and his laboratory colleagues at TSRI have explored TRF2's functions in more detail.
"We found that TRF2 uses a two-step mechanism to protect chromosome ends," said Keiji Okamoto, a postdoctoral fellow in Lazzerini Denchi's laboratory who was the lead author of the new study.
TRF2 is a complex protein with four functional domains (regions). Okamoto probed the specific functions of these four domains by creating artificial TRF2-like proteins -- in which one or more functional domains were replaced with non-functional "dummy" domains. By studying how these artificial TRF2s functioned in cells, he could determine the separate functions of each individual domain.
Uncovering Distinct Roles
Two of these domains turned out to have distinct roles in suppressing the DNA damage response. "One domain, called TRFH, blocks localization of the DNA damage factor ?H2AX, the initial step in the DNA response pathway," said Okamoto. It may do so by inducing a structural change in telomeres that hides it from the DNA damage machinery. A distinct region of TRF2, which Okamoto dubbed iDDR (inhibitor of the DNA damage response pathway), independently and actively suppresses the transduction of the DNA damage signal downstream of ?H2AX.
Okamoto and colleagues found that the iDDR region works in part by recruiting an enzymatic activity associated with the tumor suppressor protein BRCA1. Defects in BRCA1 lead to DNA misrepairs, genomic instability and a sharp rise in cancer risk. (Certain BRCA1 mutations bring a greater than 50-percent lifetime risk of breast or ovarian cancer.) This new finding hints that BRCA1 defects may result in defects in telomere protection, too.
Lazzerini Denchi, Okamoto and their colleagues now plan to explore TRF2's functions and protein partners in further detail, in cell studies and in transgenic mice. "We want to address the BRCA1 connection more thoroughly, too, for example, to determine the importance of its association with telomeres in preventing tumors," Lazzerini Denchi said.
The study was supported in part by a Pew Scholars Award, the Novartis Advanced Discovery Institute, the National Institutes for Health (AG038677), the National Center for Research Resources (5P41RR011823-17) and the National Institute of General Medical Sciences (8 P41 GM103533-17).
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The above story is reprinted from materials provided by The Scripps Research Institute.
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Journal Reference:
- Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K. Diedrich, John R. Yates III, Eros Lazzerini Denchi. A two-step mechanism for TRF2-mediated chromosome-end protection. Nature, 2013; DOI: 10.1038/nature11873
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/ShqGl8TpoVY/130206131004.htm
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Friday, February 1, 2013
The Top 8 Do's and Don'ts When Selling Your NJ Home
?The Top 8 Do?s and Don?ts When Selling Your NJ Home
As a Morris County, NJ Home Stager there are universal do?s and don?ts when it comes to selling your home.?? Let Let?s get right to it!
Selling Don?ts:
1. Play Realtor and insist you know what your home is worth. Hire a professional Realtor and let them do their job! ?They are the experts and know the market. ?This is the most important ?don?t? when selling your home, bar none! ?
2. Neglect curb appeal ? it?s buyer?s first impression of your home on MLS (where 90% of buyer?s start their home search) and in person. Hire a landscaper or do it yourself. Don?t forget to trim hedges, add fresh mulch and blow debris clear from walkways, porch and driveway. ?
3. Clean your home by stuffing your junk into every available storage space. Once your
home is on the market, it?s a given that buyers will look in your cabinets, pantry and open closet doors to determine storage space. If your storage areas are crammed with ?stuff?, you?re giving the impression that their things won?t fit either.
4. Fill your home with Glad Plugins and similar products. It?s the same as spraying perfume in lieu of a shower - it doesn?t work and buyers suspect you?re covering up unpleasant odors. Clean is the only smell buyers love! ?
5. Wait until the week of open house to discard or store unnecessary furniture, personal collections and family photos. This is when you call on family or friends to store things you don?t absolutely need. If that?s not an option you can call PODS ? the newest, fastest growing self-storage units. This serves two purposes: you?ll have far less to do once you sell and showcase the room?s square footage.
6. Assume buyers are going to take on your deferred maintenance like, leaky faucets, broken doorbells, chipped molding, running toilettes and/or torn screens. ?Buyers want turnkey homes. Moreover, you don?t want give buyer?s the impression your home isn?t well maintained. ???
7. Assume buyers are pet lovers ? many aren?t or are allergic to cats and dogs. ?During showings and open houses, temporarily take pets and all trances of them out of the home. Yes, this is a hassle, but it?s temporary and your goal is to sell quickly.
8. Make buyers guess a room?s purpose. If you?re selling your home as a 4 bedroom, return an office, playroom or a gym back to a bedroom. ??
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Selling Do?s
1.Find a reputable Realtor and let them price your home based on their market knowledge, research and comparable homes in your area. ?Statistically 90% of people think their home is worth more than it is?! ?Defer to your Realtor and trust they understand the market and are experts at pricing homes!
2. Shampoo your rugs (area and wall to wall) so they are clean and order free. You can hire a local carpet cleaning company or rent one from your local grocery store.
3. Paint the interior of your home in neutral colors. Nothing cleans, deodorizes and brightens 
up a home more effectively than a fresh coat of paint. Moreover, it yields the highest return on investment at 150%. ?Consult a Morris County NJ Home Stager for tried and true neutral wall colors that have mass appeal.
4. Your master bedroom should be non-gender specific. Invest in neutral bedding and add some decorative pillows. Look to high-end hotels, designed to appeal to the masses. ?Grandma?s homemade quilt won?t help sell your home! ???
5. Take down heavy, dated window treatments. Buyers love natural light and it?s better to have no window treatments than dated curtains that block the light. While you?re at it remove all dusty floral arrangements that went out with the eighties. Just trust me on this one!
6. Open all your windows and air out your home even if it?s cold out. Turn down your heat for a half hour and use fans for a cross breeze or wait for a windy day. 20 minutes is all it takes rid your home of musty, stagnate air and replace it with fresh, clean air!
7. Take out the guess work for buyers and give every room a purpose. ?If you?re selling your home as a 4 bedroom, but have been using one for an office, playroom or home gym, return it to a bedroom. ?
8. Invest in a NJ home staging consultation. Home stagers are experts on preparing your home for the market. They understand and can implement all the necessary changes that will yeild the biggest bang for your buck, while giving your home the necessary competitive edge it needs in today?s market.
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Elite Staging and Redesign - Kristine Ginsberg - 201 602 2562
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Home Staging Morris County - Staged to Sell, Designed to Live!
You have 90 seconds to make a great first impression once your home goes on the
market. Consult a Morris County professional home stager serving Union, Essex, Sussex Counties for that competitive edge so your home stands out from the competition, selling faster and for top dollar! ?
Elite Staging and Redesign offers home staging services to North Jersey homeowners, real estate agents, banks, builders, and investors in preparing homes to stand out in today?s real estate market. For a consultation on vacant staging, lived in homes or interior redesign projects call Elite Staging and Redesign at 201-602-2562.
Morris County Home Staging Website: Elite?Staging?and Redesign
Morris County Staging:?Portfolio
Email: Kris@elitestagingandredesign.com
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Source: http://activerain.com/blogsview/3605325/the-top-8-do-s-and-don-ts-when-selling-your-nj-home
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